IL-13, PGE2, and PGI2 increased the activity of PKC in HSCs. HSCs were treated with the solvent of drugs (control), 5 μM IL-13, 2 μM PGE2, and 2 μM PGI2. PKC activity assay results showing the enhanced optical density (OD) of PKC activity in response to IL-13, PGE2, and PGI2 compared to the control. Data are shown as the means ±SD. All differences were considered significant when * P<0.05 (n=5) compared with the solvent of drugs (Control).