Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 7;46(7):3339–3350. doi: 10.1093/nar/gky080

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 3. — PLZF and EZH2 share common target genes. (A) Venn diagrams showing the association between PLZF, EZH2 and SUZ12 bound regions at promoter (−2.5kb/+0.1 kb from TSS) and gene body (+0.1 kb from TSS to TES) regions. Association between two peaks was considered if they were localized on the same genomic feature of the same gene. NS not significant, ***P < 0.001 (hypergeometric test). (B) Percentages of H3K4me3 unique, H3K27me3 unique or H3K4me3/H3K27me3 marks in EZH2/PLZF (without SUZ12) or EZH2/SUZ12 (without PLZF) target genes, at promoter (Prom.) or gene body (Genbd.). (C) UCSC genome browser views of EZH2, PLZF and SUZ12 ChIP-seq and associated histone marks in KG1 cells. (D) ChIP-qPCR analysis of PLZF, EZH2 and SUZ12 on selected target genes. Percentages of bound DNA over input are shown as a mean ±SD of two independent experiments (n = 3–5). (E) Motif search at PLZF, EZH2 or PLZF/EZH2 summit regions.