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Proposed functional role of N4-cytosine methylation in the pathogenesis and gene regulation of H. pylori. Diagrammatic illustration explaining the differential occurrence of phenotypically diverse population of H. pylori based on HpyAII R-M system variations. Representation of HpyAII R-M system, phase variable region of R.hpyAII gene (poly-adenine residues) are shown with solid black vertical lines.
