Table 6. Summary and the statistical analyses of the breast tissue cores with the rate of CTLA-4 positivity in different groups of the breast carcinomas.

Carcinoma type	Median-age	Total (n)	Positive (n)	Positive (%)
Group I
Ductal carcinoma, in-situ	42.5	8	3	37.5%
Group II
Ductal carcinoma, invasive	49.5	73	40	54.8%
Grade I	42	4	4	100%
Grade II	47	55	32	58.2%
Grade III	46.5	14	4	28.6%
Group III
Lobular carcinoma, invasive	48	10	4	40.0%
Group IV
Tubular carcinoma, invasive	48	2	2	100%
All Four Groups	47	93	49	52.7%
2x2 table Fisher Exact statistical test		§Negatives (n)	*Positives (n)	Two-tailed p-Value
(G-I) Ductal carcinoma, in-situ		5	3	0.46
(G-II) Ductal carcinoma, invasive, all grades		33	40
Ductal carcinoma, invasive, grade I		0	4	0.15
Ductal carcinoma, invasive, grade II		23	32
Ductal carcinoma, invasive, grade II		23	32	0.07
Ductal carcinoma, invasive, grade III		10	4
Ductal carcinoma, invasive, grade I		0	4	0.02
Ductal carcinoma, invasive, grade III		10	4
(G-III) Lobular carcinoma, invasive		6	4	0.50
(G-II) Ductal carcinoma, invasive, all grades		33	40
(G-IV) Tubular carcinoma, invasive		0	2	0.50
(G-II) Ductal carcinoma, invasive, all grades		33	40

CTLA-4, cytotoxic T lymphocyte associated protein-4; G, Group

^§, Negatives include samples interpreted as Negative “0” and Negative “2a” (Table 5)

*, Positives include samples interpreted as LoPos “1b” and Positive “2b” (Table 5)