Table 3. Overall concordance obtained between different experiments undertaken in invasion tumours.
Abbreviations: EXPR: Expression (IHC); METH: Methylation (promoter); DEL: Deletion; OVERALL: overall alterations (Deletion+ Methylation);DYS: Dysplasia; HNSCC: Head and neck squamous cell carcinoma; H: High; M: Moderate; L: Low; ND: Not done; NOR: Normal; TUM: Tumor; B: Basal; P: Parabasal; S: Spinous. P value represents level of significance.
| REG | RBSP3: ALTERATIONS IN HNSCC | LIMD1: ALTERATIONS IN HNSCC | CDC25A: ALTERATIONS IN HNSCC | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NO. | PROTEIN EXP | METH | DEL | OVER | PROTEIN EXP | METH | DEL | OVER | PROTEIN EXP | METH | DEL | ||||||||||||
| NOR | TUM | NOR | TUM | ALL | NOR | TUM | NOR | TUM | ALL | NOR | TUM | NOR | TU | ||||||||||
| B/ P | S | B/ P | S | B/ P | S | B/ P | S | B/ P | S | B/ P | S | ||||||||||||
| 3962 | L | M | M | - | - | - | + | + | H | M | M | - | - | - | - | - | H | M | M | - | - | - | - |
| 4095 | L | M | H | + | - | - | - | - | H | M | M | - | - | + | - | + | M | M | M | - | - | - | - |
| 3981 | L | H | M | + | - | + | - | + | M | M | L | - | - | + | + | + | M | M | M | - | - | - | - |
| 3422 | L | H | M | + | - | - | - | - | L | L | L | + | + | + | + | + | H | H | M | - | - | - | + |
| 3294 | M | H | H | - | - | - | - | - | L | L | L | + | - | + | - | + | M | M | L | - | - | - | + |
| 4893 | L | M | M | + | + | - | - | - | M | M | L | - | - | + | + | + | M | M | M | - | - | - | - |
| 1941 | L | H | L | + | - | + | + | + | H | H | M | - | - | - | - | - | H | H | H | - | - | - | - |
| 3569 | L | H | H | + | - | - | - | - | H | H | M | - | - | + | - | + | H | H | M | - | - | - | - |
| 5111 | L | H | L | + | - | + | + | + | H | M | L | - | - | - | + | + | L | L | L | - | - | - | - |
| 4567 | M | M | M | - | - | + | - | + | M | M | H | - | - | - | - | - | H | M | M | - | - | - | + |
| 1882 | L | H | M | + | - | + | - | + | H | M | L | - | - | + | - | + | H | M | H | - | - | - | - |
| 1652 | L | H | M | - | - | - | - | - | H | H | L | - | - | - | + | + | L | L | L | - | - | - | + |
| 1976 | L | H | L | + | - | - | + | + | H | M | L | - | - | - | - | - | H | M | M | - | - | - | - |
| 2118 | L | L | L | + | + | + | - | + | M | M | L | - | - | + | - | + | M | M | M | - | - | - | + |
| 1215 | L | M | M | + | + | - | + | + | L | L | H | - | + | - | - | - | M | M | M | - | - | - | - |
| 5852 | H | H | L | - | - | + | + | + | H | M | H | - | - | - | - | - | H | H | M | - | - | - | - |
| 3674 | L | H | L | + | - | + | - | + | H | M | L | - | - | + | - | + | L | L | L | - | - | - | + |
| 1439 | M | H | M | - | - | + | - | + | H | M | L | - | - | + | - | + | H | H | L | - | - | - | + |
| 2117 | L | H | L | + | - | + | + | + | L | L | L | + | - | + | - | + | H | H | H | - | - | - | - |
| 1231 | L | H | H | + | - | - | - | - | H | M | H | - | - | - | - | - | L | L | L | - | - | - | - |
| 1339 | L | L | L | + | + | + | + | + | M | L | M | - | + | - | - | - | H | H | M | - | - | - | - |
| 1226 | M | M | M | + | - | - | - | - | M | L | L | - | - | + | + | + | L | L | L | - | - | - | + |
| 1500 | M | H | H | - | - | - | - | - | H | M | M | - | - | - | - | - | M | M | H | - | - | - | - |
| 1740 | L | M | L | + | + | + | - | + | H | M | M | - | - | - | + | + | M | M | L | - | - | - | + |
| 2036 | L | M | L | + | + | - | + | + | L | L | L | + | - | + | - | + | L | L | L | - | - | - | - |
| 1973 | L | H | L | + | - | - | + | + | H | H | L | - | - | + | + | + | H | H | M | - | - | - | + |
| 1445 | M | H | L | - | - | - | + | + | H | M | L | - | - | + | + | + | H | M | H | - | - | - | - |
| 4663 | L | H | M | + | - | - | - | - | L | L | L | + | - | + | + | + | H | M | M | - | - | - | - |
| 2287 | M | H | H | + | - | - | - | - | L | L | L | + | + | + | - | + | H | H | M | - | - | - | - |
| 1898 | L | H | L | - | - | - | + | + | L | L | M | + | - | + | - | + | L | L | L | - | - | - | + |
| 2209 | L | M | M | + | - | - | - | - | H | H | L | - | - | + | + | + | H | H | H | - | - | - | - |
| 3052 | L | L | L | + | - | + | + | + | M | M | H | - | - | - | - | - | H | M | H | - | - | - | - |
| 1306 | L | H | M | - | + | - | - | - | H | M | L | - | + | + | + | + | H | M | M | - | - | - | + |
| 1812 | L | M | L | + | - | + | + | + | H | M | L | - | - | - | + | + | H | H | L | - | - | - | + |
| 2041 | L | H | M | + | - | - | + | + | H | M | L | - | - | + | + | + | M | M | M | - | - | - | - |
| 2201 | L | M | L | + | - | + | + | + | M | L | L | - | - | + | + | + | M | M | M | - | - | - | - |
| 2670 | L | H | H | + | - | - | - | - | L | L | L | + | - | + | + | + | H | M | L | - | - | - | - |
| 1340 | H | H | L | - | - | + | - | + | M | M | H | - | + | - | - | - | M | M | L | - | - | - | - |
| 3934 | L | L | L | + | - | + | + | + | H | L | M | - | - | - | - | - | H | H | M | - | - | - | - |
| 1545 | L | M | L | + | - | - | - | - | H | M | M | - | - | - | - | - | L | M | L | - | - | - | - |
| 2041 | L | M | M | ND | ND | - | + | + | M | L | L | ND | ND | + | + | + | M | M | M | - | - | - | - |
| 2118 | L | H | M | ND | ND | + | - | + | H | M | M | ND | ND | + | - | + | H | H | L | - | - | - | + |
| 2201 | M | M | L | ND | ND | + | + | + | H | M | L | ND | ND | + | + | + | M | M | L | - | - | - | - |
| 3284 | L | M | L | ND | ND | - | + | + | H | M | L | ND | ND | - | + | + | M | M | L | - | - | - | + |
| 3636 | L | L | L | ND | ND | - | + | + | L | L | L | ND | ND | + | + | + | M | M | L | - | - | - | + |
| 3804 | L | H | L | ND | ND | + | - | + | H | M | L | ND | ND | + | + | + | L | M | L | - | - | - | + |
| 3533 | L | H | L | ND | ND | - | + | + | M | M | L | ND | ND | + | + | + | H | H | L | - | - | - | + |
| 280 | M | M | L | ND | ND | + | + | + | H | H | L | ND | ND | + | + | + | H | H | L | - | - | - | + |
| 1973 | L | M | L | ND | ND | + | + | + | H | H | L | ND | ND | - | + | + | M | M | L | - | - | - | + |
| 3798 | H | H | L | ND | ND | + | + | + | L | L | M | ND | ND | + | - | + | H | M | L | - | - | - | + |
| 725 | L | L | L | ND | ND | - | + | + | M | M | M | ND | ND | - | + | + | M | M | M | - | - | - | - |
| 3131 | M | M | H | ND | ND | + | - | + | H | H | L | ND | ND | + | - | + | H | H | L | - | - | - | - |
| 3258 | L | M | L | ND | ND | - | + | + | H | M | L | ND | ND | + | + | + | L | L | M | - | - | - | - |
| 1445 | L | L | L | ND | ND | - | + | + | H | H | L | ND | ND | + | + | + | H | H | M | - | - | - | - |
| 3758 | M | H | M | ND | ND | - | - | - | H | M | M | ND | ND | + | - | + | M | M | L | - | - | - | - |
| 5272 | L | M | L | ND | ND | + | + | + | L | L | H | ND | ND | - | - | - | L | M | L | - | - | - | - |
| 4203 | L | M | M | ND | ND | + | - | + | H | M | L | ND | ND | + | + | + | M | M | L | - | - | - | + |
| 4480 | L | H | H | ND | ND | - | - | - | H | M | M | ND | ND | + | - | + | H | M | L | - | - | - | - |
| 5438 | L | H | L | ND | ND | + | + | + | M | L | H | ND | ND | - | - | - | M | M | L | - | - | - | + |
| 1652 | L | L | M | ND | ND | - | - | - | M | M | L | ND | ND | - | + | + | L | L | M | - | - | - | + |
| 1268 | L | H | L | ND | ND | - | + | + | M | L | L | ND | ND | + | - | + | H | H | L | - | - | - | + |
| 1812 | L | M | L | ND | ND | + | + | + | H | M | L | ND | ND | - | + | + | L | L | L | - | - | - | + |
| 1750 | L | M | M | ND | ND | - | - | - | M | M | L | ND | ND | - | - | - | M | M | M | - | - | - | - |
| 1231 | L | L | M | ND | ND | - | - | - | L | L | M | ND | ND | - | - | - | H | M | M | - | - | - | - |