Skip to main content
. 2018 Feb 8;114(6):846–857. doi: 10.1093/cvr/cvy040

Figure 2.

Figure 2

Some Lamin A mutants have a dramatically abnormal intranuclear localization. Cellular localization of human EGFP-AdV-WT-LMNA and mutants (E161K, D192G, N195K). Laser scanning confocal immunofluorescence microscopy images of NRVMs cells stained for actin-stress fibers with phalloidin, (F-Actin) (red left-middle column) and GFP (green, right middle column). The nuclei are stained in DAPI (blue, left column). Right column: an overlay of the three channels. Particularly evident appear the intranuclear blebs in N195K mutant cells, visible also in E161K and D192G. Bar 50 μm (n = 4).