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. 2018 Mar 17;20(4):401–409. doi: 10.1016/j.neo.2018.01.012

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Resistance to inhibitors of the MAPK pathway restores CEACAM1 expression.

Vemurafenib-resistant (Vem-Res) and selumetinib-resistant (Sel-Res) sublines of 624mel and 526mel cells were tested. (A) The restored expression of pERK. The graph shows the ratio of each indicated protein as normalized according to actin using densitometry. (B) The restored expression of CEACAM1 using flow cytometry. Shaded histograms represent staining with secondary reagent only. Parental (Parent.) and resistant (Res) histograms are indicated in each panel. (C) The effect of each treatment on CEACAM1 isoform expression (long, short) using. RT-PCR. Results are depicted as fold change (RQ) of the parental cell control. Figure shows a representative experiment out of three performed.