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. 2018 Mar 6;20(4):351–363. doi: 10.1016/j.neo.2018.01.011

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© 2018 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

(A) p-STAT3 (Tyr 705) immunostaining in TMA prostate tissue specimens. (B) Quantification of mean p-STAT3 (Tyr 705) nuclear staining intensity H-score in prostate tissue microarray. Specimens are categorized as no alteration in EAF2 or p53 expression (Neither), upregulated p53 (p53+), downregulated EAF2 (EAF2−), or concurrent upregulation of p53 and downregulation of EAF2 (Both). Scoring was quantified for patients with p-STAT3, EAF2, and p53 immunostaining scores; specimens missing either p-STAT3, EAF2, or p53 data due to tissue loss during the immunostaining process were not included (number of patients in parentheses, *P < .05, **P < .01, ****P < .0001).