Table 5. Effect of Dha Administration on urinary Eicosanoid Excretion.
Pre-DHA | Post-DHA | p Value | |
---|---|---|---|
umol per mg creatinine | |||
F2-IsoPs | 1.42 (0.08) | 1.4 (0.7) | 0.91 |
PGI-M | 0.8 (0.3) | 0.7 (0.2) | 0.18 |
PGE- M | 5.2 (2.1) | 4.8 (2.1) | 0.43 |
PGD- M | 1.0 (0.5) | 0.9 (0.4) | 0.44 |
LTE4 | 0.02 (.03) | 0.08 (0.0) | 0.27 |
Eicosanoid concentration per mg. creatinine, measured in early morning spot urine collection before and after DHA administration. Data shown as mean (+/- SD).
F2-IsoPs=F2-isoprostanes
PGI-M=2,3-dinor-6-keto-prostaglandin F1a.
PGE-M =Prostaglandin E2 metabolite (9,15-dioxo-11α-hydroxy-13,14-dihydro-2,3,4,5-tetranor- prostan-1,20-dioic acid)
PGD-M = Prostaglandin D2 metabolite (9α-hydroxy-11,15-dioxo-13,14-dihydro-2,3,4,5-tetranor- prostan-1,20-dioic acid)
LTE4 = Leukotriene E4