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. Author manuscript; available in PMC: 2018 Apr 20.
Published in final edited form as: Lancet Neurol. 2015 Apr;14(4):388–405. doi: 10.1016/S1474-4422(15)70016-5

Figure 2. Micro- and astroglial changes in Alzheimer´s disease brain and APP/PS1 mice.

Figure 2

(A) CD11b positive microglia (blue) within a Aβ deposit (brown) in the parietal cortex of a human AD brain section (bar = 50 μm). (B) Activated, Iba1-positive microglia (green) at a Aβ plaque site (red) in a section of a APP/PS1 transgenic mouse (bar = 50 μm). (C) GFAP positive astrocytes (blue) surround the site of Aβ deposition (brown) in the parietal cortex of a human AD brain section (bar = 100 μm). (D) GFAP-positive astrocytes (green) at a Aβ plaque site (red) in a section of a APP/PS1 transgenic mouse (bar = 50 μm). (E) Interleukin-1β positive microglia (brown) in the frontal cortex of a human AD brain section (bar = 25 μm). Courtesy of Drs. Markus Kummer and Michael Heneka.