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. Author manuscript; available in PMC: 2018 Apr 20.
Published in final edited form as: Lancet Neurol. 2015 Apr;14(4):388–405. doi: 10.1016/S1474-4422(15)70016-5

Figure 3. Amyloidogenic processing of the amyloid precursor protein (APP).

Figure 3

APP is processed by subsequent cleavages of two aspartate-proteases: the β-side cleaving enzyme 1 (BACE1) and the presenilin 1 and 2, which are part of the γ-secretase complex. BACE1 cleavage generates a C-terminal fragment (β-CTF) that is finally processed by presenilin 1 or 2 to liberate the amyloid β peptide, that is prone to aggregate into oligomers.