Table 3.
Relationship between PRS based on 83,890 SNP’s with inclusion criterion into PRS of p<.5, by CCSp stroke subtype for European Ancestry Adults
| Phenotype (CCSp) | Total N cases | Total N Controls | Betas | SE | p for betas | OR (95%CI) for Stroke, Per 1 s.d. of PRS* = ebeta*s.d. |
|---|---|---|---|---|---|---|
| All stroke | 12,577 | 25,643 | 0.000043 | 0.000019 | .025 | 1.03 (1.00, 1.05) |
| LAA | 2,229 | 25,643 | 0.000031 | 0.000038 | 0.406 | 1.02 (0.98, 1.07) |
| SAO | 2,029 | 25,643 | 0.000132 | 0.000039 | 0.001 | 1.08 (1.03, 1.13) |
| CE | 3,400 | 25,643 | 0.000065 | 0.000032 | 0.0419 | 1.04 (1.00, 1.08) |
| OTHER | 612 | 25,643 | 0.000087 | 0.00007 | 0.205 | 1.05 (0.97, 1.14) |
| Crypto | 963 | 25,643 | 0.000090 | 0.000056 | 0.106 | 1.06 (0.99, 1.13) |
CCSp is the Causative Classification System - phenotypic
*
1 sd of PRS in SiGN is approximately 600 units
Betas relates PRS to stroke subtype, per unit of PRS