Table 4.
Relationship between PRS based on 83,890 SNP’s with inclusion criterion into PRS of p<.5, by CCSp stroke subtype for African Ancestry
| Phenotype (CCSp) | Total N cases | Total N Controls | Betas | SE | p for betas | OR (95%CI) for Stroke, Per 1 s.d. of PRS* = ebeta*s.d. |
|---|---|---|---|---|---|---|
| All stroke | 1353 | 2383 | 0.000108 | 0.000039 | 0.001 | 1.08 (1.04, 1.13) |
| LAA | 220 | 2383 | 0.000191 | 0.000089 | 0.032 | 1.12 (1.01, 1.25) |
| SAO | 390 | 2383 | 0.000150 | 0.000069 | 0.029 | 1.09 (1.01, 1.19) |
| CE | 208 | 2383 | −0.00002 | 0.000089 | 0.816 | 0.99 (0.89, 1.10) |
| OTHER | 106 | 2383 | 0.000155 | 0.000126 | 0.219 | 1.10 (0.95, 1.27) |
| Crypto | 133 | 2383 | 0.00012 | 0.000110 | 0.285 | 1.07 (0.94, 1.22) |
CCSp is the Causative Classification System - phenotypic
*
1 sd of PRS in SiGN is approximately 600 units
Betas relates PRS to stroke subtype, per unit of PRS