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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Childs Nerv Syst. 2017 Sep 6;33(10):1693–1701. doi: 10.1007/s00381-017-3474-2

Figure 1.

Figure 1

Timeline of key investigations for the development and utilization of contemporary pediatric traumatic brain injury (TBI) models. Rats have been used across all of the rodent pediatric TBI models, while mice have been largely limited to controlled cortical impact. All of these models have been used to study severe TBI, except that the closed head modifications of controlled cortical impact have been used to study mild TBI and repetitive mild TBI given the emerging importance of mild TBI and concussion in the current era. Please see text for details.