Table 5.

Incidence of adverse drug reactions caused by trimethoprim/sulfamethoxazole prophylaxis

	Number of cases*	Incidence rate (95% CI)†
Adverse drug reactions	34	20.6 (14.3 to 28.6)
Anaemia	2	1.2 (0.1 to 4.2)
Leucopenia	1	0.6 (0.0 to 3.3)
Thrombocytopenia	3	1.8 (0.4 to 5.2)
GI problems	2	1.2 (0.1 to 4.2)
LFT abnormality	6	3.5 (1.3 to 7.7)
Skin rash	6	3.5 (1.3 to 7.7)
Azotaemia	5	3.0 (1.0 to 7.1)
Hyperkalaemia	3	1.8 (0.4 to 5.2)
Others‡	6	3.5 (1.3 to 7.7)
Serious adverse drug reactions	2	1.2 (0.1 to 4.2)
Pancytopenia	1	0.6 (0.0 to 3.3)
Stevens-Johnson syndrome	1	0.6 (0.0 to 3.3)

*Total observation period was 170.1 person-years for 262 cases.

†Rate per 100 person-years.

‡Including headache (1), anorexia (1), eosinophilia (1), tingling sensation (1) and pruritus (2).

GI, gastrointestinal; LFT, liver function test.