Table 4.
Investigation results: (A) MRI, (B) CSF, (C) EEG
| A.MRI | ||||||
| Diagnosis | Normal (%) | Atrophy (%) | Either BG and/or cortex* (%) | BG and cortex* (%) | BG alone* (%) | Cortex alone* (%) |
| CJD | 12/171 (7) | 70/178 (40) | 158/171 (92) | 112/171 (66) | 13/171 (8) | 33/171 (19) |
| Not CJD | 9/47 (19) | 26/47 (55) | 2/47 (4) | 0 | 1/47 (2) | 1/47 (2) |
| Fisher’s exact test | P=0.02 | P=0.07 | P<0.001 | P<0.001 | P=0.31 | P=0.003 |
| B.CSF | ||||||
| Group | 14-3-3 present (%) | S100B elevated (%) | RT-QuIC (%) | |||
| sCJD | 112/130 (86) | 108/128 (84) | 67/75 (89) | |||
| Other diagnosis | 13/25 (48) | 12/18 (67) | 0/25 (0) | |||
| Fisher’s exact test | P<0.001 | P=0.094 | P<0.001 | |||
| C.EEG | ||||||
| Group | Normal (%) | Slow waves (%) | PSWC (%) | |||
| sCJD | 11/186 (6) | 154/186† (83) | 67/186 (36) | |||
| Other diagnosis | 5/40 (13) | 25/40 (63) | 2/40‡ (5) | |||
| Fisher’s exact test | P<0.17 | P=0.009 | P<0.001 | |||
*Refers to the consensus opinion of a consultant neuroradiologist and consultant neurologist about the diffusion-weighted images of the BG or cerebral cortex.
†Includes patients who had PSWC.
‡One patient had SSPE type complexes, the other hepatic encephalopathy.
BG, basal ganglia; CJD, Creutzfeldt-Jakob disease; sCJD, sporadic CJD; PSWC, periodic sharp wave complexes; SSPE, subacute sclerosing panencephalitis.