Table 2.
Likelihood of overall response according to gene mutations and cytogenetic abnormalities
| All patients | Treatment naïve | Relapsed/refractory | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Mutation | OD | 95% CI | P | OD | 95% CI | P | OD | 95% CI | P |
| IGHV unmutated | 0.613 | 0.315-1.19 | .148 | 1.818 | 0.639-5.171 | .262 | 0.310 | 0.111-0.869 | .026 |
| Del(17p) | 0.294 | 0.144-0.601 | <.001 | 0.153 | 0.033-0.711 | .019 | 0.386 | 0.171-0.871 | .031 |
| Del(11q) | 0.510 | 0.284-0.915 | .032 | 0.292 | 0.101-0.842 | .026 | 0.660 | 0.325-1.339 | .275 |
| Tri(12) | 0.961 | 0.491-1.882 | 1.000 | 1.133 | 0.357-3.600 | 1.000 | 0.801 | 0.344-1.866 | .663 |
| Del(13p) | 0.877 | 0.501-1.533 | .672 | 0.810 | 0.290-2.256 | .800 | 0.917 | 0.467-1.800 | .864 |
| TP53 | 0.203 | 0.096-0.427 | <.001 | 0.206 | 0.042-1.009 | .057 | 0.217 | 0.093-0.508 | <.001 |
| Complex karyotype | 0.412 | 0.202-0.840 | .022 | 0.848 | 0.153-4.709 | 1.000 | 0.402 | 0.176-0.917 | .035 |
| ATM | 1.329 | 0.462-3.83 | .800 | 1.147 | 0.219-5.998 | 1.000 | 1.307 | 0.325-5.254 | 1.000 |
| KRAS | 0.176 | 0.033-0.930 | .034 | 0.060 | 0.003-1.293 | .057 | 0.356 | 0.058-2.191 | .348 |
| MGA | 0.377 | 0.122-1.161 | .122 | 2.408 | 0.098-48.532 | 1.000 | 0.214 | 0.053-0.863 | .035 |
| SF3B1 | 0.617 | 0.306-1.246 | .193 | 2.151 | 0.440-10.506 | .502 | 0.368 | 0.155-0.875 | .025 |
| DDX3X | 0.033 | 0.002-0.597 | <.001 | 0.328 | 0.006-17.049 | 1.000 | 0.038 | 0.002-0.692 | .002 |
| IKZF3 | 0.337 | 0.074-1.544 | .213 | 0.312 | 0.019-5.23 | .431 | 0.356 | 0.058-2.19 | .348 |