Table 1.
Comparative studies for treatment of post-operative atrial fibrillation
| Type of surgery |
Lung surgery (Nojiri et al.21) |
|
|---|---|---|
| Number of patients | Landiolol n = 15 | Control n = 15 |
| Rate of conversion to SR | at 2 h 8/15 (53%) | at 2 h 3/15 (20%) |
| at 12 h 11/15 (73%) | at 12 h 8/15 (53%) | |
| Time to convert to SR | 8.1 ± 11.0 h | 23.0 ± 26.0 h, |
| Landiolol dose used | Ten patients at 5 mcg/kg/min | 0.25 mg digoxin |
| Five patients at 10 mcg/kg/min | +5 mg verapamil on day 1 | |
|
Adverse events |
Pneumonia (n = 1) |
Pneumonia (n = 4) |
| hypotension (n = 2) | ||
|
acute respiratory distress syndrome (n = 1) | ||
| Type of surgery |
Oesophagectomy (Niwa et al.28) |
|
|
Number of patients |
Landiolol n = 8 |
Control n = 13 |
| Rate of conversion to SR | at 2 h 5/8 (62.5%) | at 2 h 1/13 (7.7%) |
| at 12 h 8/8 (100%) | at 12 h 7/13 (53.8%) | |
| Time to convert to SR | 3.6 ± 6.6 h | 23.3 ± 5.2 h |
| Landiolol dose used | 6.5 ± 3.4 mcg/kg/min | Digoxin (n = 11) |
| subsequently increased to | Verapamil (n = 6) | |
| 7.7 ± 4.4 mcg/kg/min | Disopyramide (n = 3) | |
| Adverse events | AF recurrence (n = 1) | AF recurrence (n = 3) |
| SBP<90 mmHg/HR<50 b.p.m. (n = 1) | ||
a
A single digoxin dose of 0.25 mg may have been too low as compared to usual dose that allow titration up to two times 0.5 mg per day.
SR, sinus rhythm.