Table 1.
Characterization of LPNs (mean ± SD, n=3)
| LPN | FA-LPNs | VCR/LPNs | FA-VCR/LPNs |
|---|---|---|---|
| formulations | |||
| Particle size (nm) | 168.7±4.6 | 171.2±5.2 | 174.1±5.5 |
| Polydispersity index | 0.152±0.019 | 0.169±0.021 | 0.182±0.030 |
| Zeta potential (mV) | −30.6±2.7 | −35.4±3.1 | −32.7±3.7 |
| VCR EE (%) | N/A | 93.2±2.9 | 91.4±3.2 |
| VCR DL (%) | N/A | 5.3±0.8 | 4.8±0.7 |
Abbreviations: LPNs, lipid-polymer hybrid nanoparticles; FA-LPNs, folic acid-decorated LPNs; VCR, vincristine; VCR/LPNs, VCR-loaded LPNs; FA-VCR/LPNs, folic acid-decorated VCR-loaded LPNs; EE, drug encapsulation efficiency; DL, drug loading efficiency; N/A, not applicable.