Table 2.

Pharmacokinetic parameters of VCR after intravenous administration of formulations to mice (mean ± SD, n=6)

Pharmacokinetic parameters	Free VCR	VCR/LPNs	FA-VCR/LPNs
AUC(0→72) (µg⋅h/mL)	18.29±2.08	346.43±23.28*	377.24±26.17*
AUC(0→∞) (µg⋅h/mL)	19.34±2.34	387.21±31.19*	412.36±33.25*
MRT (h)	2.89±0.36	8.98±0.76*	10.32±0.95*
t1/2 (h)	1.88±0.27	5.86±0.67*	6.94±0.52*
Ke (h−1)	0.43±0.06	0.21±0.04*	0.16±0.03*

Note:

^*P < 0.05 compared with free VCR.

Abbreviations: LPNs, Lipid-polymer hybrid nanoparticles; FA-LPNs, folic acid-decorated LPNs; VCR, vincristine; VCR/LPNs, VCR-loaded LPNs; FA-VCR/LPNs, folic acid-decorated VCR-loaded LPNs; AUC, area under the curve; MRT, mean residence time; t_1/2, half-life; K_e, terminal elimination rate.