Table S1.
Chi-square test on grouped PDYN genotype distribution in total and gender-specific African American groups
| A) | Total cannabis-dependent cohort, n=110 | Control, n=122 | OR | p-value | ||||
|---|---|---|---|---|---|---|---|---|
| SS | SL | LL | SS | SL | LL | |||
| Genotype | 32 | 38 | 40 | 27 | 42 | 53 | 1.18 (SS+SL) vs LL | NS |
| Frequency | 29% | 35% | 36% | 22% | 34% | 44% | ||
| B) | Male cannabis-dependent subsample, n=74 | Control, n=50 | OR | p-value | ||||
| SS | SL | LL | SS | SL | LL | |||
| Genotype | 22 | 28 | 24 | 14 | 16 | 20 | 1.39 (SS+SL) vs LL | NS |
| Frequency | 30% | 38% | 32% | 28% | 32% | 40% | ||
| C) | Female cannabis-dependent subsample, n=36 | Control, n=72 | OR | p-value | ||||
| SS | SL | LL | SS | SL | LL | |||
| Genotype | 10 | 10 | 16 | 13 | 26 | 33 | 1.06 (SS+SL) vs LL | NS |
| Frequency | 28% | 28% | 44% | 18% | 36% | 46% | ||
Note: p-value was determined by the Fisher’s exact test.
Abbreviations: LL, long–long; NS, not significant; PDYN, prodynorphin; SL, short–long; SS, short–short.