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. 2018 Apr 16;13:1195–1205. doi: 10.2147/COPD.S159666

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© 2018 Storgaard et al. This work is published and licensed by Dove Medical Press Limited

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Fitted exacerbation rates (combined reported exacerbations and hospitalized exacerbations) (A, B) and hospital admission rates (C, D).

Notes: In (A and C), blue (control) and red (HFNC) bars show rates per group as randomized (intention-to-treat analysis). In (B and D), the regression line for exacerbations (B) and admissions (D) relates actual device use, zero for the control group and 12 months for the study completers, with withdrawal subjects ranging in between (per-protocol analysis) to the number of events per patient, showing longer actual use giving lower rates of exacerbation and admission.

Abbreviation: HFNC, high-flow nasal cannula.