Table 1.
Background information on the randomized study population, humidified HFNC-treated patients and controls at baseline
| Variables at baseline | HFNC-treated patients (n=100) | Controls (n=100) | p-value for group difference |
|---|---|---|---|
| Sex, % female | 56 | 63 | NS |
| Age, years | 71.0 (8.2) | 70.4 (9.0) | NS |
| Treated with LTOT prior to inclusion, months | 28.9 (32.6) | 33.5 (30.6) | NS |
| BMI, kg/m2 | 25.0 (6.4) | 25.4 (6.0) | NS |
| Smoking status, N, never/present/former | 1/14/85 | 0/26/74 | NS |
| Pack-years | 41.7 (17.8) | 40.5 (19.5) | NS |
| mMRC score | 3.3 (0.9) | 2.9 (0.9) | 0.008 |
| Exacerbations in the preceding year | 3.23 (3.1) | 2.9 (2.8) | NS |
| Current oxygen flow, L | 1.6 (0.7) | 1.6 (0.8) | NS |
| pH | 7.41 (0.04) | 7.41 (0.02) | NS |
| PaCO2, kPa | 6.5 (1.3) | 6.4 (1.0) | NS |
| PaO2, kPa* | 9.9 (1.8) | 9.9 (1.7) | NS |
| SaO2 | 95 (3.1) | 95 (2.7) | NS |
| FEV1% | 29.8 (12.6) | 31.8 (12.9) | NS |
| FVC% | 64.1 (18.2) | 63.9 (19.0) | NS |
| FEV1/FVC | 37.5 (11.1) | 40.2 (10.3) | NS |
| 6MWT (N), m | (91) 254.6 (89.2) | (96) 245.2 (85.0) | NS |
| Borg score, end of test | 6.3 (2.3) | 6.2 (2.3) | NS |
| HFNC flow, L | 20 (1.1) | ||
| Oxygen supply with HFNC, L | 1.75 (0.8) | ||
| pH after 30 minutes of HFNC | 7.42 (0.03) | ||
| PaCO2 after 30 minutes of HFNC, kPa | 6.2 (1.2) | ||
| PaO2 after 30 minutes of HFNC, kPa | 8.9 (1.2) | ||
| SaO2 after 30 minutes of HFNC, kPa | 94 (2.6) |
Notes: Results are presented as mean (SD) unless otherwise stated.
*
ABG on usual supplementary oxygen supply.
Abbreviations: ABG, arterial blood gas; BMI, body mass index; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; HFNC, high-flow nasal cannula; LTOT, long-term oxygen therapy; mMRC, modified Medical Research Council; 6MWT, 6-minute walk test; NS, nonsignificant; Pa, arterial partial pressure; Sa, arterial saturation.