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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Brain Behav Immun. 2017 Jul 1;66:56–69. doi: 10.1016/j.bbi.2017.06.018

Figure 5. Histopathological evaluation in colons after Cr infection.

Figure 5

(A–C) Representative BrdU immunohistochemistry and hematoxylin counter-stained sections and microscopy of colons at PID12 after Cr infection. (D) Pathology index for mucosal hyperplasia scored for severity and extent from 0 to 4. (E) Epithelial crypt proliferation indicated by BrdU incorporation. Morphometric analyses reveal (F) increased mucosal depth (double-headed arrows) in response to Cr in both sham- and CCI-injured mice and (G) increased colonic smooth muscle response (asterisk) to Cr in CCI+Cr groups. Values are means ± SEM; (D–F) *P<0.05, **P<0.01, compared to uninfected shams; (G) **P<0.01, compared to uninfected controls; #P<0.05, compared to sham+Cr; n=6–8.