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. Author manuscript; available in PMC: 2019 Apr 18.
Published in final edited form as: Neuron. 2018 Apr 5;98(2):380–393.e4. doi: 10.1016/j.neuron.2018.03.018

Figure 7. 1NM-PP1 inhibits hippocampal GABAergic transmission in T796G mice.

Figure 7

(A) Diagram of recording a pyramidal neuron (grey) that was innervated by an interneuron (yellow).

(B) Represent traces of mIPSC before, during and after 1NM-PP1 application.

(C) Time course of 1NM-PP1 inhibition of mIPSC frequency on hippocampal slices from T796G mice, but not control mice (control n=6 neurons (3 mice); T796G n=9 neurons (4 mice); one way ANOVA, ***P<0.001).

(D) No effect of 1NM-PP1 on mIPSC amplitude on hippocampal slices of either genotype (control n=6 neurons (3 mice); T796G n=9 neurons (4 mice); one way ANOVA, ns, p=0.9935).

(E) Represent traces of eIPSC before, during and after 1NM-PP1 application in control and T796G mice.

(F) 1NM-PP1 inhibition of eIPSC amplitude in hippocampal slices from T796G (n=6 neurons (3 mice), t-test, **P=0.0011; *p=0.0294) but not control mice (n=7 neurons (3 mice), t-test, ns, p=0.8534; ns, p=0.9675; ns: not significant).

(G) Represent traces of paired-pulse (interval 0.25s) stimuli.

(H) Increased eIPSC paired-pulse ratio by 1NM-PP1 (n=6 neurons (3 mice), one way ANOVA, **p=0.0013).

Pooled data are shown as mean ± SEM. See also Figure S7, S8.