TABLE 1.
Demographic, Clinical and Neuropathological Characteristics by Clinical Diagnosis Category
| Clinical diagnosis | ||||
|---|---|---|---|---|
| NCI (n = 10) | AD (n = 14) | Total (n = 24) | p value | |
| Age (years) at death: | ||||
| Mean ± SD (Range) | 84.3 ± 5.3 (74.0–93.0) | 85.1 ± 6.6 (69.0–94.0) | 84.8 ± 5.9 (69.0–94.0) | 0.60 m |
| Number (%) of males: | 6 (50.0%) | 6 (50.0%) | 12 (50.0%) | 0.68 f |
| MMSE: Mean ± SD (Range) | 27.0 ± 1.5 (25-30) | 16.9 ± 7.8 (6-25) | 21.1 ± 7.8 (6-30) | 0.0001 m |
| PMI (h): | ||||
| Mean ± SD (Range) | 6.7 ± 3.2 (2.2–11.0) | 6.6 ± 2.8 (3.0–10.7) | 6.6 ± 2.9 (2.2–11.0) | 0.80 m |
| Braak scores: | ||||
| 0 | 2 | 0 | 2 | |
| I/II | 2 | 0 | 2 | 0.0001 m |
| III/IV | 6 | 4 | 10 | |
| V/VI | 0 | 10 | 10 | |
| CERAD diagnosis: | ||||
| No AD | 5 | 0 | 5 | |
| Possible | 5 | 0 | 5 | |
| Probable | 0 | 5 | 5 | 0.001 m |
| Definite | 0 | 9 | 9 | |
| NIA-RI diagnosis | ||||
| No AD | 2 | 0 | 2 | |
| Low | 4 | 0 | 4 | |
| Intermediate | 4 | 6 | 10 | 0.0001 m |
| High | 0 | 8 | 8 | |
NCI, no cognitive impairment; AD, Alzheimer disease; PMI, postmortem interval; MMSE, Mini-Mental State Examination; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease; NIA-RI, National Institute on Aging-Reagan Institute; f Fisher’s exact test; m Mann-Whitney U test.