Table 3.
HCC odds ratiosa and 95% confidence interval (OR, 95% CI) associated with the lifestyle (X-set) and the NMR clusters (Y-set) PLS scores in the main analysis (N = 336, X-set = 21, Y-set = 285)
| PLS lifestyle variables X-scores | PLS NMR Variables Y-scores | ||||
|---|---|---|---|---|---|
| Factor | ORb (95% CI) | P-Waldc | Factor | ORb (95% CI) | P-Waldc |
| 1 | 0.77 (0.58, 1.02) | 0.07 | 1 | 0.96 (0.91, 1.01) | 0.09 |
| 2 | 1.54 (1.06, 2.25) | 0.02 | 2 | 1.11 (1.02, 1.22) | 0.02 |
| 3 | 1.37 (1.05, 1.79) | 0.02 | 3 | 1.22 (1.04, 1.44) | 0.01 |
aModels were adjusted for C-reactive protein concentration, alpha-fetoprotein concentration and a composite score for liver damage. Cases and controls were matched on age at blood collection (± 1 year), sex, study centre, date (± 2 months) and time of the day at blood collection (± 3h), fasting status at blood collection (<3/3–6/>6h); among women, additional matching criteria included menopausal status (pre-/peri-/postmenopausal) and hormone replacement therapy use at time of blood collection (yes/no).
bORs expressing the change in HCC risk associated to 1SD increase in the score.
cWald’s test was for continuous exposure compared with a Chi-square distribution with 1 degree of freedom (dof).