Table 5.
HCC odds ratiosa and 95% confidence intervals (OR, 95%CI) associated with the lifestyle (X-set) and the NMR clusters (Y-set) PLS scores in the sensitivity analysis (N=271, 92 cases, 179 controls)
| PLS lifestyle variables X-scores | PLS NMR variables Y-scores | ||||
|---|---|---|---|---|---|
| Factor | ORb (95% CI) | P-Waldc | Factor | ORb (95% CI) | P-Waldc |
| 1 | 0.80 (0.60, 1.08) | 0.15 | 1 | 0.96 (0.94, 1.04) | 0.56 |
| 2 | 1.56 (1.02, 2.40) | 0.04 | 2 | 1.18 (1.03, 1.36) | 0.02 |
| 3 | 0.86 (0.67, 1.11) | 0.26 | 3 | 0.86 (0.73, 0.99) | <0.05 |
The sensitivity analysis was conducted excluding sets where cases were diagnosed within the first 2 years of follow-up (X-set = 21, Y-set = 285).
aModels were adjusted for C-reactive protein concentration, alpha-fetoprotein concentration and a composite score for liver damage. Cases and controls were matched on age at blood collection (± 1 year), sex, study centre, date (± 2 months) and time of the day at blood collection (± 3h), fasting status at blood collection (<3/3–6/>6h); among women, additional matching criteria included menopausal status (pre-/peri-/postmenopausal) and hormone replacement therapy use at time of blood collection (yes/no).
bORs expressing the change in HCC risk associated to 1SD increase in the score.
cWald’s test was for continuous exposure compared with a Chi-square distribution with 1 degree of freedom (dof).