Table 3.
Summary of in vivo MN and carcinogenicity studies in mice presented Figure 2 (tba, tumour-bearing animals)
| MN (genotoxicity endpoint) | Carcinogenicity (tumour endpoint) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Compound | Strain | Sex | Route | Tissue | Duration exposure (days) | Vehicle control | Sampling time | Source | BMDL05 (mg/kg/day) | BMDU05 (mg/kg/day) | Source | Strain | Sex | Route | Exposure time (weeks) | Duration experiment (weeks) | Severity | Tissue | Tissue lesion | BMDL10 (mg/kg/day) | BMDU10 (mg/kg/day) |
| aaf | bdf1 | m | ip | Blood | 1 | na | 48 | Asano [12] | 1.2 | 4.4 | CPD | bcn | m | Feed | 96 | 104 | D | Bladder | Mixed | 1.6 | 2.0 |
| acd | B6 | m | ip | Blood | 1 | Corn oil | 48 | ntp A95392 | 10.1 | 60.5 | TR-042 | b6c | f | ip | 51 | 81 | A | Lymphoid | Lymphocytic and granulocytic neoplasm | 0.20 | 0.48 |
| ace | B6 | f | inh | Blood | 91 | Air | 24 | ntp A41659 | 21.7 | 201.0 | TR-447 | b6c | m | inh | 104 | 104 | A | NA | NA | 633.7 | NA |
| age | B6 | m | ip | bm | 3 | PBS | 24 | ntp 446759 | 2.8 | 7.6 | TR-376 | b6c | m | inh | 103 | 103 | B | Nasal cavity | Adenoma | 12.7 | 43.0 |
| ams | B6 | f | inh | Blood | 91 | Air | 24 | ntp A36497 | 104.3 | 302.6 | TR-543 | b6c | f | inh | 105 | 105 | E | Liver | Adenocarcinoma | 98.8 | 504.9 |
| azt | B6 | m | gav | Blood | 90 | na | 24 | ntp A88072 | 0.3 | 0.7 | TR-469 | b6c | f | gav | 105 | 105 | E | Vagina | Squamous carcinoma papilloma | 69.1 | 136.5 |
| bap | bdf1 | m | gav | Blood | 1 | na | 48 | Shimada [15] | 0.1 | 0.4 | CPD | b6c | f | Feed | 96 | 104 | D | Forestomach | Mixed | 0.6 | 1.0 |
| ben | P16 | m | gav | Blood | 32 | Corn oil | 24 | ntp A65367 | 0.1 | 0.2 | TR-289 | b6c | m | gav | 103 | 103 | C | Preputial gland | Carcinoma | 12.4 | 18.1 |
| but | B6 | m | inh | bm | 14 | Air | 24 | ntp A74454 | 3.6 | 11.8 | TR-288 | b6c | m | inh | 60 | 60 | E | Lung | Adenocarcinoma | 14.7 | 52.3 |
| cbc | bdf1 | m | ip | bm | 1 | na | 48 | Morita [16] | 0.05 | 0.14 | CDP | swiss | f | ip | 26 | 78 | F | tba | tba mix | 0.001 | 0.015 |
| chl | B6 | m | ip | bm | 3 | PBS | 24 | ntp 518954 | 38.0 | 107.2 | TR-502 | b6c | f | gav | 105 | 105 | B | Pituitary gland | adenoma | 70.0 | 96.3 |
| coc | B6 | f | dermal | Blood | 91 | Ethanol | 24 | ntp A44271 | 47.3 | 150.8 | TR-479 | b6c | f | Dermal | 104 | 104 | E | Liver | Adenocarcinoma hepatoblastoma | 1.7 | 11.6 |
| cop | cd1 | m | ip | bm | 2 | na | 48 | Morita [16] | 4.2 | 13.2 | TR-063 | b6c | m | Feed | 96 | 96 | C | Liver | Adenocarcinoma | 522.1 | 960.0 |
| cpa | bigblue | m | ip | blood | 1 | na | 48 | Gorelick [17] | 0.1 | 0.5 | CPD | swiss | f | ip | 26 | 79 | F | tba | tba mix | 0.25 | 1.19 |
| cps | B6 | m | ip | bm | 3 | Corn oil | 24 | ntp A64289 | 17.8 | 85.4 | TR-501 | b6c | f | Feed | 104 | 104 | C | Skin | Skin sarcoma | 30.4 | 66.0 |
| dbcp | cd1 | m | ip | bm | 1 | na | 48 | Morita [16] | 1.4 | 5.0 | TR-028 | b6c | f | inh | 91 | 104 | D | Mix | Mix | 0.28 | 0.68 |
| dbe | B6 | m | inh | Blood | 175 | Air | 24 | ntp A71010 | 0.8 | 4.4 | TR-086 | b6c | f | inh | 96 | 104 | F | tba | tba mix | 0.39 | 2.50 |
| dcn | B6 | m | inh | Blood | 91 | Air | 24 | ntp A40482 | 4.9 | 27.7 | TR-513 | b6c | f | inh | 105 | 105 | C | Uterus | Stromal polyp scarcoma | 380.7 | 1147.6 |
| dhp | B6 | m | ip | bm | 3 | PBS | 24 | ntp 224367 | 28.0 | 125.2 | TR-287 | b6c | m | gav | 103 | 103 | A | NA | NA | 178.1 | NA |
| dmvc | B6 | m | ip | bm | 3 | Corn oil | 24 | ntp A50288 | 3.0 | 8.9 | TR-316 | b6c | f | gav | 103 | 103 | C | Forestomach | Carcinoma | 14.9 | 22.1 |
| eth | B6 | m | ip | bm | 3 | Corn oil | 24 | ntp 299785 | 21.0 | 62.9 | TR-237 | b6c | f | gav | 103 | 103 | E | Liver | Adenocarcinoma | 45.9 | 94.7 |
| for | B6 | m | ip | bm | 3 | Corn oil | 24 | ntp 142011 | 33.5 | 113.1 | TR-000 (67-66-3) | b6c | f | gav | 93 | 93 | E | Liver | Carcinogenic myelosarcoma | 5.1 | 14.8 |
| gly | P16 | m | gav | Blood | 280 | Water | 24 | ntp A92101 | 1.3 | 5.1 | TR-374 | b6c | m | gav | 104 | 104 | E | Liver | Adenocarcinoma | 4.5 | 26.4 |
| hrc | B6 | m | ip | bm | 3 | Corn oil | 24 | ntp A27137 | 13.2 | NA | TR-330 | b6c | m | gav | 104 | 104 | E | Harderian gland | Adenocarcinoma | 57.7 | 156.5 |
| hyd | B6 | m | ip | bm | 3 | PBS | 24 | ntp A06686 | 2.8 | 7.4 | TR-366 | b6c | f | gav | 104 | 104 | E | Liver | Adenocarcinoma | 19.4 | 63.1 |
| ieg | B6 | f | gav | Blood | 91 | Corn oil | 24 | ntp A67394 | 2.2 | 38.6 | TR-551 | b6c | m | gav | 105 | 105 | E | Liver | Adenocarcinoma | 7.1 | 30.1 |
| isn | B6 | f | inh | Blood | 91 | Air | 24 | ntp A87798 | 50.6 | 153.9 | TR-448 | b6c | f | inh | 103 | 103 | E | Lung | Adenocarcinoma | 39.1 | 178.5 |
| iso | B6 | m | inh | bm | 91 | Air | 24 | ntp A63977 | 13.6 | 40.5 | TR-486 | b6c | m | inh | 72 | 72 | E | Liver | Hepatocellular adenocarcinoma | 211.2 | 1113.5 |
| las | B6 | m | ip | bm | 3 | PBS | 24 | ntp 521899 | 69.7 | 204.7 | TR-247 | b6c | m | Feed | 103 | 103 | A | NA | NA | 815520 | NA |
| leu | B6 | f | feed | Blood | 28 | Feed | 24 | ntp A31156 | 38.8 | NA | TR-527 | b6c | f | Feed | 104 | 104 | E | Liver | Adenocarcinoma | 25.6 | 121.0 |
| mbr | B6 | m | inh | Blood | 14 | Air | 24 | ntp A51339 | 10.3 | 33.2 | TR-385 | b6c | m | inh | 104 | 104 | A | NA | NA | 318.3 | NA |
| mel | cd1 | m | ip | bm | 1 | na | 24 | Morita [16] | 0.008 | 0.038 | CPD | swiss | f | ip | 26 | 79 | F | tba | tba mix | 0.0 | 0.0 |
| mnu | balb | m | ip | Blood | 1 | NaCl | 48 | Vrzoc [14] | 0.1 | 0.3 | CPD | c3h | m | Water | 30 | 54 | E | Stomach | Glandular adenocarcinoma | 2.6 | 6.3 |
| mon | B6 | m | ip | bm | 3 | Corn oil | 24 | ntp 279574 | 8.9 | 34.9 | TR-266 | b6c | m | Feed | 104 | 104 | E | Liver | Adenocarcinoma | 2161 | NA |
| nda | 0 | m | ip | Blood | 1 | na | 48 | Suzuki [20] | 0.1 | 4.0 | CPD | cbl | f | gav | 50 | 72 | F | tba | tba mix | 0.018 | 0.048 |
| oxy | B6 | m | ip | bm | 3 | Corn oil | 24 | ntp 427822 | 8.8 | 45.9 | TR-205 | b6c | f | Feed | 104 | 104 | E | Liver | Adenocarcinoma | 15.7 | 38.3 |
| pch | B6 | m | gav | bm | 3 | PBS | 24 | ntp A79778 | 0.7 | 2.9 | TR-351 | b6c | m | gav | 103 | 103 | C | Liver | Haemangiosarcoma | 16.3 | 41.3 |
| pge | B6 | f | inh | Blood | 91 | Air | 24 | ntp A04540 | 139.5 | 538.3 | TR-515 | b6c | m | inh | 104 | 104 | E | liver | Adenocarcinoma | 79.2 | 407.5 |
| phe | B6 | m | ip | bm | 3 | PBS | 24 | ntp 874983 | 13.3 | 40.8 | TR-203 | b6c | m | Water | 103 | 103 | A | NA | NA | 108690 | NA |
| php | P16 | f | feed | Blood | 42 | Feed | 24 | ntp A93723 | 4.3 | 14.4 | TR-465 | b6c | f | Feed | 104 | 104 | C | Haematopoetic system | Haematopoetic lymphosarcoma | 567.4 | 1187.2 |
| rsc | B6 | m | ip | bm | 3 | PBS | 24 | ntp A90027 | 12.1 | 48.8 | TR-403 | b6c | m | gav | 104 | 104 | A | NA | NA | 1774.6 | NA |
| scd | AM3 | m | feed | Blood | 65 | Water | 24 | ntp A73280 | 0.5 | 1.4 | TR-546 | b6c | f | Water | 104 | 104 | E | Small intestine | Adenocarcinoma | 3.4 | 6.1 |
| sel | B6 | m | ip | bm | 3 | Corn oil | 24 | ntp A25043 | 1.5 | 8.1 | TR-194 | b6c | f | gav | 103 | 103 | E | Liver | Adenocarcinoma | 14.0 | 27.6 |
| tac | B6 | m | ip | bm | 3 | PBS | 24 | ntp 256727 | 3.5 | 9.4 | TR-200 | b6c | f | Feed | 104 | 104 | B | Pituitary gland | Adenoma | 11.8 | NA |
| tce | B6 | m | gav | bm | 3 | Corn oil | 24 | ntp 679194 | 290.7 | NA | TR-002 | b6c | m | gav | 104 | 104 | C | Liver | Carcinoma | 230.5 | 377.8 |
| teo | B6 | m | gav | Blood | 91 | Corn oil | 24 | ntp A24621 | 18.5 | 355.4 | TR-473 | b6c | m | gav | 104 | 104 | E | Liver | Hepatocellular adenocarcinoma | 296.6 | NA |
| tet | B6 | f | feed | Blood | 91 | Feed | 24 | ntp A72450 | 10.6 | 25.7 | TR-027 | b6c | f | gav | 90 | 90 | C | Liver | Carcinoma | 25.9 | 39.0 |
| ure | B6 | f | water | Blood | 91 | Water | 24 | ntp A86637 | 0.28 | 0.73 | TR-510 | b6c | m | Water | 104 | 104 | E | Harderian gland | Adenocarcinoma | 0.62 | 1.2 |