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. 2018 Apr 20;13(4):e0196040. doi: 10.1371/journal.pone.0196040

Fig 4. Homing of adoptively transferred DiD-BM-MDSCs to established metastases.

Fig 4

A) Representative in vivo images of Luc-PyMT metastases (BL signal) 3 weeks after i.c. injection into C57Bl/6 mice. B) Representative ex vivo images of DiD-BM-MDSC (FL signal; top panel) localization to adrenal gland metastases (BL signal; bottom panel). DiD-BM-MDSCs were injected (i.v.) into mice from A, and images acquired 2 weeks later. Quantification of radiant efficiency (RE) of FL-signal for the adrenal gland shown on the right. C) Representative images of spleens (left) and RE quantification (right) from treatment groups described in A and B. Naïve C57Bl/6 mice were used as controls. Data represented as mean ± SEM; *p<0.05; ***p<0.001; n = 3–5 mice for all groups.