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. 2018 Apr 20;13(4):e0195609. doi: 10.1371/journal.pone.0195609

Fig 7. Combined intervention of swimming plus metformin boosts the energy storage and improves de novo lipogenesis in GDM skeletal muscle tissues.

Fig 7

(A) Phosphorylation of GSK3β was analyzed by immunoblotting and normalized to total GSK3β proteins in skeletal muscle treated with swimming or metformin or both combined. (B) Levels of phosphorylated ACC in different groups were normalized to total ACC in the skeletal muscle treated with swimming or metformin or both combined. (C) Expression of SREBP2 was normalized to β-actin in the skeletal muscle treated with swimming or metformin or both combined. The values represent the mean ± SEM, n = 10/group. The columns with different letter (a, b, c, d) are significantly different, P<0.05 (ANOVA, SNK). All data in this figure are representatives of three independent experiments. NC: normal control group, DC: GDM control group, DS: GDM treated with swimming group, DM: GDM treated with metformin group, DSM: GDM treated with swimming plus metformin group.