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. 2018 Jan 15;29(2):111–122. doi: 10.1091/mbc.E17-03-0168

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© 2018 Barrick et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 1: — α-Catenin structure. Structure from PDB ID 4IGG (Rangarajan and Izard, 2013). (A) α-Catenin consists of three major domains: the N-terminal (N, blue), modulatory (M), and C-terminal (C, red) domains. The M domain contains three four-helix bundles: M_I (green/cyan), M_II (yellow), and M_III (orange). M_I contains the vinculin-binding site (cyan). The box indicates the region shown in B. (B) The salt bridge between D503 (M_II domain) and R551 (M_III) is part of a salt-bridge network that stabilizes the structure of the M domain.