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. 2018 Jan 15;29(2):84–95. doi: 10.1091/mbc.E17-06-0342

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© 2018 Papaioannou et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 2: — (A) Normal and scleroderma fibroblasts (n = 3, * = p < 0.05 by Student’s t test) treated with IL6xRα and SD1029. (B) The effect of SD1029 on STAT3 Y705 phosphorylation, FN1 protein, and COL1 protein in serum-starved scleroderma lung fibroblasts. (C) The effect of STAT3 down-regulation with siRNA on COL1A2 and EDA–fibronectin mRNA expression in scleroderma lung fibroblasts (n = 3, * = p < 0.05). (D) Serum-starved scleroderma lung fibroblasts were treated with IL6xRα, TGFβ, and SD1029 for 24 h before assaying COL1A2 mRNA levels (n = 3, * = p < 0.05).