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. 2018 Jan 15;29(2):84–95. doi: 10.1091/mbc.E17-06-0342

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© 2018 Papaioannou et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 3: — (A) Serum-starved lung scleroderma fibroblasts (n = 2) were treated with IL6xRα for 0.5, 2, or 16 h or left untreated. Protein was analyzed by Western blotting and densitometry. A representative blot matching the average is shown. The first histograph shows the normalized density of the bands in the Western shown here. The other histogram on the right shows the average normalized collagen levels from three independent experiments, each with a different fibroblast line (n = 3, * = p < 0.05). (B) Transcriptional analysis of COL1A1, COL1A2, and EDA–FN1 from the cell lines (n = 2) treated as in A. (C) Analysis of COL1 in the media of scleroderma (SSc) and healthy control lung fibroblasts treated with IL6xRα with or without 7.5 µM SD1029 for 16 h. (D) Transcriptional analysis of SOCS3 in response to IL6xRα. * = p < 0.05.