Skip to main content
. Author manuscript; available in PMC: 2018 Apr 20.
Published in final edited form as: J Vet Cardiol. 2015 Dec;17(Suppl 1):S53–S73. doi: 10.1016/j.jvc.2015.03.001

Figure 4.

Figure 4

Myosin binding proteins of the thick filament are shown. This simplified diagram depicts major proteins of the thick and thin filaments. Myosin ELC and RLC are shown binding to myosin S1 near the junction with myosin S2. cMyBP-C is shown in a hypothetical arrangement extending from the thick filament to the thin filament, but the precise position of cMyBP-C relative to myosin is not known. Individual cMyBP-C domains are numbered C0 to C10, starting at the N terminus of cMyBP-C. Site of the amino acid sequence abnormalities produced by the Maine Coon and Ragdoll mutations are marked by a red and a green asterisk respectively. LMM indicates light meromyosin; m, the position of the cMyBP-C regulatory motif between domains C1 and C2 that contains PKA phosphorylation sites; PA, a proline/alanine-rich linker sequence between C0 and C1; Tm, tropomyosin; TnC, troponin C; TnI, troponin I; TnT, troponin T. (From Harris et al. Circ Res 2011;108 (6): 751–764 with permission).