Table 2.
Calculations of bacterial amounts needed to infect macrophages at desired MOI.
MOI 1:1 | MOI 2:1 | MOI 4:1 | MOI 5:1 | MOI 10:1 | |
---|---|---|---|---|---|
Amount of bacteria needed to be added to 1.5 × 107 cells in 75 cm2 flask | 1.5 × 107 | 3 × 107 | 6 × 107 | 7.5 × 107 | 1.5 × 108 |
Original volume of bacteria at OD600 0.6 needed to be pelleted, ml | 0.5 | 0.5 | 1 | 1 | 2 |
Total volume of BUB that needs to be added to bacterial pellet, ml | 10 | 5 | 5 | 4 | 4 |
Concentration of bacteria in BUB suspension, bacteria/ml | 5 × 106 | 1 × 107 | 2 × 107 | 2.5 × 107 | 5 × 107 |
Volume of bacterial suspension needed to be added to 1.5 × 107 cells in 75 cm2 flask, ml | 3 | 3 | 3 | 3 | 3 |