Scheme 1.
Synthesis of the Target Compounds (R)- and (S)-24-27.
Reagents and conditions: a) BBr3, DCM, 0 °C to RT, 4 h; b) N,N′-carbonyldiimidazole, RT, overnight; c) 3N HCl, dioxane, RT, 24 h; d) 4-methoxyphenylisocyanate, RT, overnight.
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