Table 4.
List of genes in the axon guidance pathway targeted by each of the four candidate miRNAs
| Candidate miRNA | Function | Ephrins | Semaphorins | Netrins | Slits | Other genes |
|---|---|---|---|---|---|---|
| miR-125b-5p specific |
Ligand |
EFNA5 |
SEMA3E
SEMA4B
SEMA4C |
SLIT1 |
DPYSL5
GSK3B
LIMK1
MAPK3
PAK6
PPP3R2 |
|
| Receptor |
EPHA2
EPHA8
EPHB3 |
PLXNA1 |
ROBO2 |
|||
| Activator |
SRGAP2 |
|||||
| Activated |
RAC3 |
|||||
| miR-365a-3p specific |
Ligand |
EFNA3 |
SEMA6D |
ARHGEF12
RND1 |
||
| Activated |
RAC1 |
|||||
| miR-125b and miR-365a |
Ligand |
SEMA5A |
NTN1 |
NFATC4 |
||
| miR-770-5p |
Ligand |
EFNB2
EFNB3 |
SEMA6A |
ABL1
LIMK2
NCK2
NFATC3
PPP3CA
RGS3 |
||
| Receptor |
EPHA3
EPHB1 |
NRP1 |
||||
| miR-5190 |
Ligand |
SEMA3C |
MET |
|||
| Receptor |
PLXNC1 |
|||||
| miR-770 and miR-125b, or miR-365a |
Ligand |
SEMA4D
SEMA5B |
KRAS
MAPK1 |
|||
| Receptor |
EPHA7 |
UNC5C |
||||
| Activator |
SRGAP1 |
|||||
| Activated |
RAC2 |
|||||
| miR-5190 and miR-125b, and/or miR-365a | Ligand |
SLIT3 |
ABLIM3 CXCL12 NFATC2 | |||
| Receptor |
EPHA4 |
UNC5B
UNC5D |
||||
| Activator | SRGAP3 |