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. 2018 Mar 2;67(5):911–922. doi: 10.2337/db17-0850

Figure 5.

Figure 5

Embryonic deletion of Bmal1 in pancreatic β-cells does not alter postnatal development of islet morphology, postnatal islet cell expansion, or β-cell turnover. A: Representative examples of pancreatic islets stained by immunofluorescence for BMAL1 or glucagon (red) and insulin (green) and counterstained with nuclear marker DAPI (blue) imaged at ×63 (BMAL1 [scale bars, 10 µm]) and ×20 (glucagon [scale bars, 50 µm]) magnification in immature (5 days old) and mature (25 days old) β-Bmal1−/− and control β-Bmal1+/+ mice. B: Graphs showing β-cell mass, α-cell mass, proliferation, and apoptosis in immature (5 days old) and mature (25 days old) β-Bmal1+/+ and β-Bmal1−/− mouse pups. Data are expressed as mean ± SEM (n = 3–7 per group).