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Embryonic deletion of Bmal1 in pancreatic β-cells compromises postnatal functional maturation. Insulin concentration profiles during islet perifusion expressed as mean ± SEM (A) and corresponding mean fold change over baseline (B) sampled at 4 mmol/L glucose (0–32 min), 16 mmol/L glucose (32–64 min), and 4 mmol/L glucose (64–96 min) in isolated islets from immature (5 days old [n = 3]) and mature (25 days old [n = 5]) β-Bmal1−/− and control β-Bmal1+/+ mouse pups. *P < 0.05.
