Figure 7.

Embryonic deletion of Bmal1 in pancreatic β-cells modulates postnatal transcriptional maturation. Scatterplots showing biweight log₂ average expression values of all genes in mature (day 25) vs. immature (day 5) pancreatic islets of β-Bmal1^+/+ (A) and β-Bmal1^−/− (B) mice. Gray dots indicate unchanged expression, while black dots represent up- and downregulated genes with fold regulation cutoff set at 2. Tables showing significantly up- and downregulated GO biological processes with a false discovery rate (FDR) <0.05 in islets from 25-day-old mature compared with 5-day-old immature β-Bmal1^+/+ (C) and β-Bmal1^−/− (D) mouse pups. Differentially expressed genes were subjected to GO enrichment analysis using DAVID (26).