Figure 2.

C6- and C8-acylCs were elevated in patients with new-onset T2D. Fasting plasma samples were obtained from women with recent GDM who developed IGT or T2D or returned to NGT during a 2-year postpartum follow-up. Circulating S-acylCs (C2, C3, C4, and C5) (A), M-acylCs (C6, C8, C10, and C12) (B), and L-acylCs (C14, C16, and C18) (C) were profiled in their respective butylester form by quantitative SRM-MS (n = 11 for NGT, n = 13 for IGT, and n = 12 for T2D group) (D). E–H: M-acylC subspecies were subsequently profiled (n = 11 for NGT, n = 13 for IGT, and n = 12 for T2D group). Data are presented as mean ± SEM. *P < 0.05, **P < 0.01.