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. 2018 Feb 7;67(5):885–897. doi: 10.2337/db17-1150

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© 2018 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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M-acylCs decrease mitochondrial complex V expression. KIC-stimulated MMP (n = 3 for M-acylCs Physio and n = 4 for M-acylCs Patho group) (A) and KIC-stimulated OCR (n = 3/group) (B) were measured in murine islets after 28-h treatment with M-acylCs. The area under the curve (AUC) is shown as an inset. Mitochondrial gene array was performed in murine islets treated with M-acylCs in vitro, and the genes upregulated (C) and downregulated (D) >1.2 times are shown in a cluster (n = 3/group). Protein expression of oxidative phosphorylation was evaluated in murine islets treated with M-acylCs in vitro and is presented as a representative Western blot of mitochondrial complex (E) and its quantification (n = 6/group). Data are presented as mean ± SEM. *P < 0.05, **P < 0.01. FCCP, carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone; RFI, relative fluorescence intensity.