Table 1.
Characteristic | Adultsa(n = 24) | Adults (n = 10) | Adolescents (n = 12) | Pediatrics (n = 12) |
---|---|---|---|---|
Age, year | 37.1 (14.7) | 41.7 (18.1) | 14.6 (1.5) | 9.5 (1.7) |
Female, % | 67 | 90 | 50 | 42 |
Diabetes duration, year | 23.0 (14.3) | 23.7 (15.3) | 4.6 (3.3) | 4.6 (2.2) |
Insulin pump use duration, year | 12.8 (7.0) | 12.6 (8.0) | 3.2 (2.6) | 3.6 (2.1) |
Insulin dose open loop [U/(kg·d)]b | 0.61 (0.21) | 0.53 (0.24) | 0.83 (0.26) | 0.79 (0.12) |
Insulin dose 24-h HCL [U/(kg·d)]c | 0.60 (0.30) | 0.48 (0.14) | 0.83 (0.19) | 0.85 (0.16) |
HbA1c, % | 7.7 (0.9) | 7.4 (0.8) | 8.2 (0.9) | 7.8 (0.8) |
Results are mean (standard deviation) unless otherwise indicated.
Initial 24 adult subjects enrolled received 80% meal bolus; all subjects enrolled subsequently received 100% meal bolus.
Insulin dose averaged over the 7-day open-loop phase.
Insulin dose during the first 24-h HCL phase, including three meals and the overnight period.
HCL, hybrid closed loop.