FIG. 11.

pO₂ images in SCCVII tumors before and after sunitinib treatment. Longitudinal and three-dimensional EPR oxygen images (top). (A) ¹³C spectroscopic images of exogenously injected 1-¹³C-pyruvate metabolism in an SCCVII tumor. Insets are ¹³C MR spectra averaged over tumor regions. (B) Artificial images of lactate-to-total ¹³C (top) and lactate-to-pyruvate ratios (bottom) calculated from the spectroscopic images. Adapted from Ref. (41) with permission. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars