FIG. 9.
Inguinal ligation with rubber band-induced focal hypoxia and effect of hypoxia induction on treatment outcome of PIT. (A) Representative EPR images of tumor pre- and postligation. (B) Histogram of pixel values of intratumor pO2. Pre- (open bar) and postligation (filled bar) (n = 3). Results are mean ± SD. (C) Schematic of treatments for each group. (D) Kaplan–Meier plot shows inhibition of PIT effect on survival. Statistically significant difference p < 0.05 was observed in survival curve between PIT group and PIT+ligation group by log rank test (control group; n = 7, other groups; n = 6). PIT, photoimmunotherapy. Adapted from Ref. (29) with permission. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars