. 2018 Apr 1;20(4):274–284. doi: 10.1089/dia.2017.0363

Table 2.

Analysis of Daily and Nocturnal Percent of Time and Episodes with Low Glucose Levels (Full Analysis Set Population)

	CGM (DexCom G4)	Conventional therapy	Mean (95% CI) for difference CGM-conventional treatment	P
Percent of time with low glucose levels (measured by CGM during 2 weeks) below 70 mg/dL [3.9 mmol/L]
Daytime 06:00–23:59	2.73 (2.18–3.28)	4.52 (3.82–5.22)	−1.77 (−2.47 to −1.06)	<0.001
Daytime 06:00–23:59	n = 123	n = 125	n = 123	<0.001
Nighttime 00:00–05:59	2.82 (2.19–3.46)	5.45 (4.19–6.72)	−2.63 (−3.90 to −1.36)	<0.001
Nighttime 00:00–05:59	n = 123	n = 125	n = 123	<0.001
Daytime 06:00–21:59	2.81 (2.25–3.36)	4.77 (4.02–5.53)	−1.93 (−2.69 to −1.17)	<0.001
Daytime 06:00–21:59	n = 123	n = 125	n = 123	<0.001
Nighttime 22:00–05:59	2.63 (2.04–3.22)	4.74 (3.70–5.77)	−2.11 (−3.14 to −1.07)	<0.001
Nighttime 22:00–05:59	n = 123	n = 125	n = 123	<0.001
Percent of time with low glucose levels (measured by CGM during 2 weeks) below 54 mg/dL [3.0 mmol/L]
Daytime 06:00–23:59	0.76 (0.54–0.98)	1.67 (1.32–2.03)	−0.92 (−1.25 to −0.59)	<0.001
Daytime 06:00–23:59	n = 123	n = 125	n = 123	<0.001
Nighttime 00:00–05:59	0.85 (0.54–1.16)	2.46 (1.74–3.18)	−1.62 (−2.37 to −0.87)	<0.001
Nighttime 00:00–05:59	n = 123	n = 125	n = 123	<0.001
Daytime 06:00–21:59	0.77 (0.55–0.99)	1.77 (1.39–2.15)	−1.00 (−1.37 to −0.64)	<0.001
Daytime 06:00–21:59	n = 123	n = 125	n = 123	<0.001
Nighttime 22:00–05:59	0.80 (0.52–1.08)	2.08 (1.50–2.67)	−1.29 (−1.90 to −0.68)	<0.001
Nighttime 22:00–05:59	n = 123	n = 125	n = 123	<0.001
Number of low glucose episodes (measured by CGM during 2 weeks) below 70 mg/dL [3.9 mmol/L]
Whole period	11.45 (9.99–12.90)	13.51 (12.07–14.96)	−2.06 (−3.65 to −0.46)	0.01
Whole period	n = 123	n = 125	n = 123	0.01
Daytime 06:00–23:59	9.46 (8.21–10.70)	11.78 (10.45–13.12)	−2.30 (−3.73 to −0.87)	0.002
Daytime 06:00–23:59	n = 123	n = 125	n = 123	0.002
Nighttime 00:00–05:59	2.57 (2.09–3.05)	2.92 (2.42–3.42)	−0.36 (−0.94–0.22)	0.23
Nighttime 00:00–05:59	n = 123	n = 125	n = 123	0.23
Daytime 06:00–21:59	8.85 (7.69–10.02)	11.02 (9.73–12.30)	−2.13 (−3.52 to −0.74)	0.003
Daytime 06:00–21:59	n = 123	n = 125	n = 123	0.003
Nighttime 22:00–05:59	3.25 (2.69–3.81)	3.75 (3.19–4.31)	−0.50 (−1.16–0.15)	0.13
Nighttime 22:00–05:59	n = 123	n = 125	n = 123	0.13
Number of low glucose episodes (measured by CGM during 2 weeks) below 54 mg/dL [3.0 mmol/L]
Whole period	4.38 (3.56–5.21)	6.84 (5.83–7.85)	−2.46 (−3.45 to −1.47)	<0.001
Whole period	n = 123	n = 125	n = 123	<0.001
Daytime 06:00–23:59	3.50 (2.81–4.20)	5.58 (4.73–6.42)	−2.07 (−2.94 to −1.19)	<0.001
Daytime 06:00–23:59	n = 123	n = 125	n = 123	<0.001
Nighttime 00:00–05:59	1.03 (0.77–1.30)	1.76 (1.32–2.20)	−0.74 (−1.20 to −0.28)	0.002
Nighttime 00:00–05:59	n = 123	n = 125	n = 123	0.002
Daytime 06:00–21:59	3.25 (2.61–3.89)	5.17 (4.35–5.99)	−1.90 (−2.74 to −1.06)	<0.001
Daytime 06:00–21:59	n = 123	n = 125	n = 123	<0.001
Nighttime 22:00–05:59	1.33 (1.00–1.67)	2.14 (1.68–2.61)	−0.83 (−1.32 to −0.34)	0.001
Nighttime 22:00–05:59	n = 123	n = 125	n = 123	0.001

For continuous variables, mean, 95% CI, and n are presented. Fisher's nonparametric permutation test for crossover design was used.