. 2018 Apr 1;20(4):274–284. doi: 10.1089/dia.2017.0363

Table 3.

Analysis of Daily And Nocturnal Glycemic Variability Estimated By Standard Deviation, Coefficient of Variation, And Mean Amplitude of Glycemic Excursions from Glucose Levels (Full Analysis Set Population)

	CGM (Dexcom G4)	Conventional therapy	Least square mean (95% CI)^afor difference CGM-conventional treatment	P
SD of glucose levels (mg/dL) (measured by CGM during 2 weeks)
Daytime 06:00–23:59	69.31 (67.09–71.53)	77.49 (75.14–79.84)	−8.42 (−10.69 to −6.15)	<0.001
Daytime 06:00–23:59	n = 123	n = 125	−8.42 (−10.69 to −6.15)	<0.001
Nighttime 00:00–05:59	64.33 (61.52–67.13)	71.32 (68.20–74.43)	−7.16 (−10.59 to −3.74)	<0.001
Nighttime 00:00–05:59	n = 123	n = 125	−7.16 (−10.59 to −3.74)	<0.001
Daytime 06:00–21:59	68.86 (66.63–71.10)	76.71 (74.28–79.14)	−8.07 (−10.50 to −5.63)	<0.001
Daytime 06:00–21:59	n = 123	n = 125	−8.07 (−10.50 to −5.63)	<0.001
Nighttime 22:00–05:59	66.17 (63.51–68.83)	74.33 (71.50–77.17)	−8.37 (−11.40 to −5.34)	<0.001
Nighttime 22:00–05:59	n = 123	n = 125	−8.37 (−11.40 to −5.34)	<0.001
CV of glucose levels (mg/dL) (measured by CGM during 2 weeks)
Daytime 06:00–23:59	0.37 (0.36–0.38)	0.41 (0.39–0.42)	−0.04 (−0.05 to −0.03)	<0.001
Daytime 06:00–23:59	n = 123	n = 125	−0.04 (−0.05 to −0.03)	<0.001
Nighttime 00:00–05:59	0.35 (0.33–0.36)	0.38 (0.36–0.40)	−0.03 (−0.05 to −0.02)	<0.001
Nighttime 00:00–05:59	n = 123	n = 125	−0.03 (−0.05 to −0.02)	<0.001
Daytime 06:00–21:59	0.37 (0.36–0.38)	0.41 (0.40–0.42)	−0.04 (−0.05 to −0.03)	<0.001
Daytime 06:00–21:59	n = 123	n = 125	−0.04 (−0.05 to −0.03)	<0.001
Nighttime 22:00–05:59	0.35 (0.34–0.36)	0.38 (0.37–0.40)	−0.04 (−0.05 to −0.02)	<0.001
Nighttime 22:00–05:59	n = 123	n = 125	−0.04 (−0.05 to −0.02)	<0.001
MAGE of glucose levels (mg/dL) (measured by CGM during 2 weeks)
Daytime 06:00–23:59	159.10 (154.11–164.10)	180.23 (174.64–185.81)	−21.39 (−27.08 to −15.71)	<0.001
Daytime 06:00–23:59	n = 123	n = 127	−21.39 (−27.08 to −15.71)	<0.001
Nighttime 00:00–05:59	148.61 (141.68–155.54)	163.68 (156.14–171.21)	−15.59 (−24.57 to −6.60)	<0.001
Nighttime 00:00–05:59	n = 119	n = 124	−15.59 (−24.57 to −6.60)	<0.001
Daytime 06:00–21:59	159.29 (154.31–164.28)	178.33 (172.62–184.04)	−18.88 (−24.76 to −13.01)	<0.001
Daytime 06:00–21:59	n = 123	n = 127	−18.88 (−24.76 to −13.01)	<0.001
Nighttime 22:00–05:59	154.00 (147.58–160.41)	169.05 (162.41–175.68)	−15.70 (−23.28 to −8.12)	<0.001
Nighttime 22:00–05:59	n = 121	n = 126	−15.70 (−23.28 to −8.12)	<0.001

For continuous variables mean, 95% CI and n are presented; For categorical variables n and percent are presented.

^{^a}

LSM (95% CI) and P-value are obtained from SAS procedure PROC GLM with sequence, patient(sequence), period, and treatment as class variables.

CV, coefficient of variation; MAGE, mean amplitude of glycemic excursions.