Figure 4.

Examples of parasite densities over time in two individual cohort members

(A) Participant VN300445: 12 months after two rounds of dihydroartemisinin and piperaquine a low-density Plasmodium falciparum infection (31 parasites per mL) was detected, which increased to 58 parasites per mL before expanding to 3 975 000 parasites per mL. The participant remained afebrile throughout the 2-year follow-up period and was not treated after the mass drug administration. (B) Participant VN300699: 9 months after three rounds of dihydroartemisinin and piperaquine, the participant had a low-density P falciparum infection. The density oscillates in the following 13 months between no detectable parasites and 529 200 parasites per mL to increase to 7 296 000 parasites per mL on the last study visit. The participant remained afebrile throughout the 2-year follow-up period and was not treated after the mass drug administration. Red lines represent mass drug administrations. Numbers on the graph represent parasite densities per mL. More individual examples are in the appendix.