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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Matrix Biol. 2018 Jan 5;67:75–89. doi: 10.1016/j.matbio.2017.12.014

Figure 6. Model showing the mechanism by which MT-COMP alters adipogenesis and osteogenesis thereby affecting murine bone.

Figure 6

The alteration in adipogenesis negatively impacts mechanical strength of bone, bone volume, trabecular bone, trabecular bone quality, articular cartilage, bone mineral density, and cortical thickness and porosity. MT-COMP expression also results in thinner ligaments, articular cartilage and increased joint laxity. Thinner articular cartilage, subchondral bone, increased joint laxity and irregular ossification of the ends of the bone (shown in blue) may contribute to early joint erosion.